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Segal Trials

What Happens When Antidepressants Aren’t Enough?

For many, depression is an invisible battle — a daily weight that colors every thought, decision, and moment. While some find relief through therapy or antidepressants, others continue to struggle despite trying multiple medications. This is known as treatment-resistant depression (TRD), and it affects a significant number of people diagnosed with Major Depressive Disorder (MDD).

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Exploring Psychedelic Research for Generalized Anxiety Disorder

Anxiety isn’t always fleeting. For millions of adults, it’s a daily, debilitating experience.
Generalized Anxiety Disorder (GAD) affects approximately 3.1% of U.S. adults each year, and many find limited relief even after trying traditional medications like SSRIs or benzodiazepines[^1]. Symptoms often include excessive worry, restlessness, sleep disturbances, and difficulty concentrating — lasting six months or more and affecting relationships, work, and daily life.

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When Schizophrenia Escalates: Understanding Acute Psychotic Episodes

What Is an Acute Psychotic Episode?

For people living with schizophrenia, there can be long stretches of stability — but sometimes, symptoms return suddenly and powerfully. These surges are known as acute psychotic episodes.

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