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Depression is one of the most common mental health conditions in the world and for some, finding the right treatment can be a long and difficult journey. At Segal Trials, we are actively researching new care options, including psychedelic-based approaches, to better understand how they might help people living with treatment-resistant depression.

What Is Treatment-Resistant Depression?
Treatment-resistant depression (TRD) refers to depression that doesn’t improve after trying two or more standard antidepressant treatments. This can leave individuals feeling frustrated, hopeless, and unsure of where to turn next.

That’s where clinical research plays a vital role.

Exploring Psychedelics in Research
Psychedelics have gained attention in recent years for their potential use in mental health care. While still under investigation, certain psychedelic compounds are being studied for how they may interact with the brain differently than traditional medications.

At Segal Trials, our research team is conducting a clinical study to evaluate one of these compounds in individuals who have not responded to other treatments for depression. The goal is to learn more about its effects, safety, and potential as a new care option.

Why Participate in a Clinical Study?
By joining a clinical trial, you’re not only exploring new options for your own care — you’re helping researchers and future patients, too. Participants in our studies often receive:

• Access to care from experienced medical staff
• No-cost study-related exams and procedures
• Compensation for time and travel (if eligible)

Who Can Join?

• Our current study is enrolling adults who:
• Are between the ages of 18 and 65
• Have been diagnosed with depression
• Have not responded well to previous treatments
• Every study has specific eligibility criteria. If you’re interested, you can see if you qualify here or contact us directly.

Shaping the Future of Mental Health Care
At Segal Trials, we’ve been dedicated to advancing mental health research since 1998. With over two decades of experience and a passionate team of experts, we’re proud to support new research that could change lives.

If you or someone you know is struggling with depression and looking for new options, a research study may be a step worth exploring.

👉 Explore Current Studies

In recent years, there has been a resurgence of interest in psychedelics as potential treatments for mental health disorders. Among the many substances being studied, N,N-Dimethyltryptamine (DMT) stands out due to its unique properties and rapid, intense effects. While traditionally associated with shamanic rituals and ayahuasca ceremonies, DMT is now being explored for its potential to alleviate anxiety. Could this powerful psychedelic be the key to unlocking relief for those struggling with anxiety disorders?

Welcome to Part 2 of our exploration into anxiety. Last year, we discussed common behaviors and symptoms associated with Social Anxiety Disorder in our blog: If You Can Relate, You May Have Social Anxiety Disorder. Today, we delve deeper, offering new insights and the latest information to help you understand this pervasive condition. If you find yourself relating to these experiences, it may be time to consider professional avenues, including potential participation in a clinical trial for anxiety.

The team at Segal Trials’ Center for Psychedelic Research closely followed the recent session of the FDA’s Psychopharmacologic Drugs Advisory Committee. This pivotal meeting focused on the New Drug Application (NDA) submitted by Lykos Therapeutics for MDMA-assisted therapy for Post-Traumatic Stress Disorder (PTSD). Despite compelling presentations and data showing significant efficacy and a low incidence of serious adverse events, the committee voted against FDA approval. This vote, however, is non-binding, and the FDA’s final decision is expected by August 11, 2024.

Welcome to the brighter side of corporate culture, where we not only navigate the choppy waters of workplace dynamics but also offer a lifeline to those struggling with mental health issues like generalized anxiety disorder, social anxiety disorder, and depression. Today, we'll delve into managing challenging personalities at work and how Segal Trials, a clinical trials company, provides alternative care options to help you thrive both professionally and personally.