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For many, depression is an invisible battle — a daily weight that colors every thought, decision, and moment. While some find relief through therapy or antidepressants, others continue to struggle despite trying multiple medications. This is known as treatment-resistant depression (TRD), and it affects a significant number of people diagnosed with Major Depressive Disorder (MDD).
For many people living with depression, treatment brings relief over time. But for others, the symptoms remain — heavy, persistent, and disruptive — even after trying medications, therapy, or both.
For many people, depression is a condition that eventually improves with the right combination of therapy, support, and medication. But for others, the road is more difficult. If you’ve tried multiple antidepressants with little or no relief, you may be living with treatment-resistant depression (TRD).