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Over the past few years, psychedelics have captured growing attention in mental health research. From psilocybin (the active compound in “magic mushrooms”) to LSD and DMT, these substances are being studied in clinical settings to better understand their potential to relieve symptoms of depression, especially in cases where traditional treatments have not worked.
For many people living with major depressive disorder (MDD), the journey to relief can be long and frustrating. Standard treatments, such as antidepressants and psychotherapy, are often the first line of care. But for some, these approaches bring only partial improvement or no improvement at all.
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For millions living with Treatment-Resistant Depression (TRD), the usual approaches, therapy, antidepressants, or both, just aren’t enough. TRD is more than just “feeling down.” It’s a relentless condition where symptoms persist despite multiple treatment attempts, leaving people stuck in cycles of medication changes, side effects, and frustration.
For many people living with depression, treatment brings relief over time. But for others, the symptoms remain — heavy, persistent, and disruptive — even after trying medications, therapy, or both.
For many people, depression is a condition that eventually improves with the right combination of therapy, support, and medication. But for others, the road is more difficult. If you’ve tried multiple antidepressants with little or no relief, you may be living with treatment-resistant depression (TRD).