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Segal Trials

What Happens When Antidepressants Aren’t Enough?

For many, depression is an invisible battle — a daily weight that colors every thought, decision, and moment. While some find relief through therapy or antidepressants, others continue to struggle despite trying multiple medications. This is known as treatment-resistant depression (TRD), and it affects a significant number of people diagnosed with Major Depressive Disorder (MDD).

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Exploring Psychedelic Research for Generalized Anxiety Disorder

Anxiety isn’t always fleeting. For millions of adults, it’s a daily, debilitating experience.
Generalized Anxiety Disorder (GAD) affects approximately 3.1% of U.S. adults each year, and many find limited relief even after trying traditional medications like SSRIs or benzodiazepines[^1]. Symptoms often include excessive worry, restlessness, sleep disturbances, and difficulty concentrating — lasting six months or more and affecting relationships, work, and daily life.

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When Schizophrenia Escalates: Understanding Acute Psychotic Episodes

What Is an Acute Psychotic Episode?

For people living with schizophrenia, there can be long stretches of stability — but sometimes, symptoms return suddenly and powerfully. These surges are known as acute psychotic episodes.

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When Nothing Works: What to Know About Treatment-Resistant Depression

What Is Treatment-Resistant Depression?

For many people, depression is a condition that eventually improves with the right combination of therapy, support, and medication. But for others, the road is more difficult. If you’ve tried multiple antidepressants with little or no relief, you may be living with treatment-resistant depression (TRD).

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What Comes After Detox? Facing the Next Step in Opioid Recovery

Detox Isn’t the Finish Line — It’s the Starting Point

Completing a short-term detox is a major milestone. It takes strength, patience, and endurance. But for many people who use opioids, the real challenge begins after withdrawal ends.

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