Understanding Bipolar Depression: When the Lows Take Over

What Bipolar Depression Really Feels Like

Bipolar disorder is often portrayed as rapid mood swings or bursts of energy followed by sadness. But in reality, one of the most painful and often overlooked parts of bipolar I or II disorder is the depressive episodes.

These episodes aren’t just “feeling down.” They can make it difficult to function, connect, or even get out of bed — sometimes for weeks or months at a time.

For people living with bipolar depression, the struggle is real, persistent, and often misunderstood.

How It’s Different from Major Depression

While symptoms of bipolar depression and major depressive disorder (MDD) can look similar — low mood, fatigue, loss of interest — they’re not the same.

People with bipolar depression often:

• Have a history of manic or hypomanic episodes (periods of high energy, impulsivity, or agitation)

• Experience more frequent mood changes

• Are more sensitive to antidepressants, which can trigger mood instability

• Often find that traditional depression treatments aren’t as effective

This makes diagnosis and treatment more complex — and underscores the need for new approaches designed specifically for bipolar-related depressive episodes.

Signs You Might Be Experiencing a Bipolar Depressive Episode

Bipolar depression can last for weeks or even months. Some common signs include:

• Feeling emotionally “flat” or disconnected

• Sleep problems (too much or too little)

• Difficulty concentrating

• Loss of energy or motivation

• Feelings of guilt or worthlessness

• Trouble enjoying things you used to love

• Withdrawing from friends or family

If these symptoms sound familiar — and you’ve also experienced past periods of high energy, restlessness, or impulsive behavior — you might be dealing with bipolar I or II disorder.

Why New Research Matters

Treating bipolar depression is especially challenging. Many available medications don’t fully address depressive symptoms — and some people experience side effects or instability on certain mood treatments.

That’s why researchers are exploring new therapies that work differently, including medications that target dopamine receptors in a more selective way — with the goal of reducing symptoms while maintaining stability.

A Clinical Study May Be an Option

Segal Trials is participating in a clinical research study evaluating an investigational medication for adults with bipolar I or II disorder who are currently experiencing a depressive episode.

You may qualify if you:

• Are between 18 and 65 years old

• Have been diagnosed with bipolar I or II disorder (without psychosis)

• Have had a depressive episode lasting 4 weeks to 12 months

• Are not currently taking psychiatric medications and meet other medical criteria

👉 Learn more or see if you qualify at SegalTrials.com

Your experience matters. And you may be helping to shape new care options for the future.