Bipolar disorder is often portrayed as rapid mood swings or bursts of energy followed by sadness. But in reality, one of the most painful and often overlooked parts of bipolar I or II disorder is the depressive episodes.
These episodes aren’t just “feeling down.” They can make it difficult to function, connect, or even get out of bed — sometimes for weeks or months at a time.
For people living with bipolar depression, the struggle is real, persistent, and often misunderstood.
While symptoms of bipolar depression and major depressive disorder (MDD) can look similar — low mood, fatigue, loss of interest — they’re not the same.
People with bipolar depression often:
Have a history of manic or hypomanic episodes (periods of high energy, impulsivity, or agitation)
Experience more frequent mood changes
Are more sensitive to antidepressants, which can trigger mood instability
Often find that traditional depression treatments aren’t as effective
This makes diagnosis and treatment more complex — and underscores the need for new approaches designed specifically for bipolar-related depressive episodes.
Bipolar depression can last for weeks or even months. Some common signs include:
Feeling emotionally “flat” or disconnected
Sleep problems (too much or too little)
Difficulty concentrating
Loss of energy or motivation
Feelings of guilt or worthlessness
Trouble enjoying things you used to love
Withdrawing from friends or family
If these symptoms sound familiar — and you’ve also experienced past periods of high energy, restlessness, or impulsive behavior — you might be dealing with bipolar I or II disorder.
Treating bipolar depression is especially challenging. Many available medications don’t fully address depressive symptoms — and some people experience side effects or instability on certain mood treatments.
That’s why researchers are exploring new therapies that work differently, including medications that target dopamine receptors in a more selective way — with the goal of reducing symptoms while maintaining stability.
Segal Trials is participating in a clinical research study evaluating an investigational medication for adults with bipolar I or II disorder who are currently experiencing a depressive episode.
You may qualify if you:
Are between 18 and 65 years old
Have been diagnosed with bipolar I or II disorder (without psychosis)
Have had a depressive episode lasting 4 weeks to 12 months
Are not currently taking psychiatric medications and meet other medical criteria
👉 Learn more or see if you qualify at SegalTrials.com
Your experience matters. And you may be helping to shape new care options for the future.