We often hear the word “depression” used casually — but for those living with major depressive disorder (MDD), it’s far more than a passing mood. Depression can affect nearly every part of a person’s life, from sleep and energy to relationships and decision-making.
And it’s more common than you might think.
Depression isn’t simply “feeling down.” It’s a medical condition that can interfere with your ability to function day-to-day. Symptoms may include:
Constant fatigue, even after rest
Difficulty concentrating or making decisions
Feelings of worthlessness or hopelessness
Loss of interest in activities you once enjoyed
Sleep disturbances — too much or too little
Changes in appetite or weight
Emotional numbness or disconnection
Thoughts of death or suicide
Many people with depression also struggle with anxiety, making their symptoms even more complex.
What makes it even harder? Sometimes, people with depression may look “fine” on the outside — while struggling deeply inside. This invisibility can make it hard to reach out or feel understood.
Depression is one of the leading causes of disability worldwide. Left untreated, it can impact physical health, increase the risk of chronic illness, and lower life expectancy. But with the right support, many people can find relief and begin to heal.
Unfortunately, not everyone responds to traditional treatments. Some individuals try multiple medications or forms of therapy without seeing improvement — this is known as treatment-resistant depression.
That’s why continued education and research are so important.
If someone in your life is living with depression, you don’t have to fix it — but your support can make a difference. Here are a few ways to help:
Listen with compassion and without judgment
Avoid saying things like “just cheer up” or “snap out of it”
Offer help with daily tasks
Encourage seeking professional help
Check in regularly, even with a simple text or call
Your presence matters more than you may realize.
Depression is real, it’s valid, and it’s treatable — but only if we talk about it openly, reduce the stigma, and continue exploring better care options for those who need them.
If you're struggling or know someone who is, know that you're not alone — and support is available.
📖 Learn more about depression from the National Institute of Mental Health
Segal Trials is committed to advancing mental health care through education and research. Visit SegalTrials.com to learn more.