Everyone feels down from time to time. But when sadness, hopelessness, and lack of interest in life persist for weeks or months, it may be more than just a rough patch—it could be Major Depressive Disorder (MDD).
MDD is one of the most common mental health conditions in the U.S., affecting an estimated 8.3% of adults each year (CDC, 2023). It’s more than just feeling “blue”—it’s a complex medical condition that affects thoughts, behaviors, energy levels, and even physical health.
Persistent low mood or sadness
Loss of interest or pleasure in activities
Changes in appetite or weight
Difficulty sleeping or sleeping too much
Fatigue or lack of energy
Feelings of worthlessness or guilt
Difficulty concentrating or making decisions
Thoughts of death or suicide
If these symptoms sound familiar and last for two weeks or more, it’s important to talk to a mental health professional. You are not alone, and help is available.
While professional care is often necessary, here are a few strategies that may help support your mental health:
Maintain a Routine
Create a daily schedule that includes sleep, meals, exercise, and self-care.
Exercise Regularly
Even short walks can help release feel-good chemicals like endorphins and reduce stress.
Stay Connected
Isolation can worsen depression. Reach out to trusted friends or family, or join a support group.
Limit Alcohol and Stimulants
Substances can interfere with mood and sleep. Try to minimize intake and stay hydrated.
Seek Professional Help
Therapy and medications can make a significant difference. If one approach hasn’t worked, don’t give up—there are many treatment options available.
Despite available treatments, many people with MDD continue to experience symptoms even after trying multiple medications. That’s why ongoing clinical research is so critical—it helps develop new options for those who haven’t found relief.
Researchers are currently studying a new investigational medication that targets the biological processes related to inflammation and stress response. If you or a loved one has been struggling with depression that hasn’t improved with standard treatment, you may qualify for a clinical research study exploring this novel approach.
🔗 Learn more about participating in research: SegalTrials.com